Alberto Morisetti publications

PUBLICATIONS

• Tolerability and toxicological profile of pixantrone (Pixuvri®) in juvenile mice. Comparative study with doxorubicin, Monica Longo, Paola Della Torre, Cecilia Allievi, Alberto Morisetti, Suliman Al-Fayoumi, Jack W. Singer, Reproductive Toxicology, Volume 46, July 2014, Pages 20-30, ISSN 0890-6238, http://dx.doi.org/10.1016/j.reprotox.2014.02.006. (http://www.sciencedirect.com/science/article/pii/S0890623814000409 )
• Ghisalberti, A; Morisetti, A; Bestetti, A; Cairo, G. Potent trophic activity of spermidine supramolecular complexes in in vitro model. World J Biol Chem 2013 August 26; 4(3): 71-78 ISSN 1949-8454 (online)
• Ramponi, S; Rebaudengo, C; Cabella C; Grotti , A; Vultaggio, S; Aime, S; Morisetti, A; Lorusso, V Contrast-enhanced MRI of murine sponge model for progressive angiogenesis assessed with gadoteridol (ProHance) and gadocoletic acid trisodium salt (B22956/1).Journal of magnetic resonance imaging : JMRI 2008;27(4):872-80
• Parolini, C, Marchesi, M Lorenzon, P Castano, M Balconi, E Miragoli, L Chaabane, L Morisetti, A Lorusso, V Martin, B J.  Bisgaier, C L. Krause, B Newton, R S. Sirtori, C R. Chiesa, G. Dose-Related Effects of Repeated ETC-216 (Recombinant Apolipoprotein A-I Milano/ 1-Palmitoyl-2-Oleoyl Phosphatidylcholine Complexes) Administrations on Rabbit Lipid-Rich Soft Plaques In Vivo Assessment by Intravascular Ultrasound and Magnetic Resonance Imaging Journal of the American College of Cardiology Vol. 51, No. 11, 2008
• Bussi, S. Fouillet, X. Morisetti A..Toxicological assessment of gadolinium release from contrast media. Experimental and Toxicologic Pathology 58 (2007) 323-330.
• Ramponi, S, Grotti, A. Morisetti, A. Vultaggio, S. ,Lorusso V. Effects of iodinated contrast media on endothelium: an in vitro study. Toxicology in vitro 21(2007): 191-196

• Rosati G., Morisetti A. and Tirone P (1992). Toxicity in animals and safety in humans of contrast media: The predictive value of animal studies. Toxicology Letters, 64/65. 705-715
• Morisetti, A. Tirone, P. Luzzani, F and de Haën C (1994)Toxicological safety assessment of iomeprol, a new X-ray contrast agent. European Journal of Radiology 18 Suppl 1  S21-S3
• de Haën, C. Anelli, P.L. Lorusso, V. Morisetti, A. Maggioni, F. Zheng, J. Uggeri, F. Cavagna F.M..Gadocoletic Acid Trisodium Salt (B22956/1). A New Blood Pool Magnetic Resonance Contrast Agent With Application in Coronary Angiography. Investigative Radiology, Volume 41, Number 3, March 2006.
• Anelli, P.L.,  Brocchetta M., Lorusso, V.,  Manfredi G., Morisetti, A., Morosini, P., Murru, M., Visigalli, M. Bile Acid at Work: Development of a new Intravascular MRI Contrast Agent. Medicinal Inorganic Chemistry” Chap. 9 – ACS Symposium series 903 edited by JL Sessler et al, 2005
• Bussi, S. Morisetti A., Margins of safety of intravascular contrast media: body weight, surface area or toxicokinetic approach. Arh Hig Rada Toksikol, Vol. 56, No. 2, 157-160, 2005 
• Anelli, P.L.,  Lattuada, L., Lorusso, V., Lux,G.,  Morisetti, A., Morosini, P. Conjugates of Gadolinium Complexes to Bile Acids as Hepatocyte-Directed Contrast Agent Resonance Imaging. Journal of Medicinal Chemistry. 2004, vol. 47, no14, pp. 3629-3641
• A. Morisetti, G. Alfieri, P. Tirone Effects of non ionic iodinated contrast media on red blood cell morphology. In vitro study by scanning electron microscopy. Pharmacology and Toxicology, 85 (Suppl II): 29, 1999.
• Morisetti A., Bussi, S. Tirone P Toxicological safety evaluation of gadobenate dimeglumine 0.5M solution for injection (MultiHance), a new MRI contrast medium. Journal of Computer Assisted Tomography, 23 (Suppl. 1): S207-S217,1999.
• Mikami, T. Daimon, H. Sagami, F. Morisetti, A. Bussi, S., Tirone P, Yamada, Y. Kimura, H. Goto K. Muscular irritation study of gadobenate dimeglumine  (E7155) in rabbits. The Journal of Toxicological Sciences, Vol. 24, Supp. I, 107-114, 1999.

• Toritsuka N; Daimon H; Sawada S; Sagami F; Tirone P; Morisetti A; Bussi S; Fassio F. Mutagenicity study of gadobenate dimeglumine (E7155)- micronucleus test in rat bone marrow cells. The Journal of Toxicological Sciences, Vol. 24, Supp. I, 103-106, 1999.
• Toritsuka N; Daimon H; Sawada S; Sagami F; Tirone P; Morisetti A; Bussi S; Adams K. Mutagenicity study of gadobenate dimeglumine (E7155)- chromosome aberration test with human lymphocytes in culture. The Journal of Toxicological Sciences, Vol. 24, Supp. I, 95-101, 1999.

• Rosati G., Morisetti A. and Tirone P (1994) Tossicità nell’animale e sicurezza nell’uomo. Il valore predittivo degli studi preclinici Rivista di Neuroradiologia 7: 595-600.
• de Haën C, Morisetti A., Bertani F., and  Tirone P.  The factor time in acute intravenous toxicity studies of contrast media. Invest Radiol , 29, Suppl. 2, S108-S110, 1994
• Morisetti, A. La Noce, A. Luzzani, F Preclinical testing results of iomeprol show promise. Diagnostic imaging Europe, Suppl. June 1995, p.10-14.
• Luzzani, F,  Morisetti, A. Bussi, S., Tirone P. Neurotolerability  of non-ionic X-ray contrast media: the role of chemotoxicity. Invest Radiol. 31, 6: 338-344, 1996.

• Luzzani, F,  Morisetti, A., Tirone P. Early and late deaths as a discriminating factor in acute toxicity studies. Pharmacol. Res 35, Suppl.110; 1997.
•   Valenti, R. Motta, A. Merlini, S Morisetti, A. Tirone, P. Iopiperidol, a new non-ionic iodinated contrast medium with promising anticoagulant and antiplatelet properties. Acad. Radiology, 1999.
• Chimoto, T. Sagami, F. Morisetti, A. Bussi, S., Tirone P. General toxicity study of gadobenate dimeglumine (E7155)- single dose intravenous  and intracisternal toxicity study in rats. The Journal of Toxicological Sciences, Vol. 24, Supp. I, 1-6, 1999.
• Sekido, T. Sagami, F. Morisetti, A. Bussi, S., Tirone P Masters R. General toxicity study of gadobenate dimeglumine (E7155)- single dose intravenous toxicity study in dogs. The Journal of Toxicological Sciences, Vol. 24, Supp. I, 7-18, 1999.
• Aoki, T, Sagami, F. Morisetti, A. Bussi, S., Tirone P Masters R.General toxicity study of gadobenate dimeglumine (E7155) -4-week repeated dose intravenous toxicity study followed by 4-week recovery period in rats. The Journal of Toxicological Sciences, Vol. 24, Supp. I, 19-39, 1999.
• Katsutani, N. Sagami, F. Morisetti, A. Bussi, S., Tirone P. Mandella R. C General toxicity study of gadobenate dimeglumine (E7155) -4-week repeated dose intravenous toxicity study followed by 4-week recovery period in dogs. The Journal of Toxicological Sciences, Vol. 24, Supp. I, 41-60, 1999.
• Okada, F. Sagami, F. Morisetti, A. Bussi, S., Tirone P, J. K Baguley. Reproductive and development toxicity study of gadobenate dimeglumine (E7155)- fertility study in male rats by intravenous administration. The Journal of Toxicological Sciences, Vol. 24, Supp. I, 61-69, 1999.
• T. Kawaguchi,T. Sagami, F. Morisetti, A. Bussi, S., Tirone P. Baguley, J. K. Reproductive and development toxicity study of gadobenate dimeglumine (E7155)- combined study of effects on fertility and embryo-fetal toxicity in female rats by intravenous administration. The Journal of Toxicological Sciences, Vol. 24, Supp. I, 71-78, 1999.
• Kawaguchi, T. Sagami, F. Morisetti, A. Bussi, S., Tirone P. Baguley, J. K. Reproductive and development toxicity study of gadobenate dimeglumine (E7155)- study of embryo-fetal toxicity in rabbits by intravenous administration. The Journal of Toxicological Sciences, Vol. 24, Supp. I, 79-87, 1999.
• Hakura, A. Sagami, F. Morisetti, A. Bussi, S., Tirone P. Fassio, F. Mutagenicity study of gadobenate dimeglumine (E7155)- reverse mutation assays in S. typhimurium and E. Coli tester strains. The Journal of Toxicological Sciences, Vol. 24, Supp. I, 89-94, 1999.
• Aime, S. Botta, M. Calabi, L. Crich S.G, Morisetti A. and Terreno E. Solution Structures and Relaxometry of Novel DOTA-like Ln(III) Complexes Featuring Improved Tolerability. Volume 1996 Issue S1 , Pages 1 – 1896 (1996) Supplement: Fourth Scientific Meeting April 27 – May 3, 1996, New York, New York, U.S.A.
• Luzzani, F,  Morisetti, A. Bussi, S., Tirone P. Neurotolerability  of non-ionic X-ray contrast media: the role of chemotoxicity. Invest Radiol. 31, 6: 338-344, 1996.
• Morisetti, A. La Noce, A. Luzzani, F Preclinical testing results of iomeprol show promise. Diagnostic imaging Europe, Suppl. June 1995, p.10-14.
• Rosati G., Morisetti A. and Tirone P (1994) Tossicità nell’animale e sicurezza nell’uomo. Il valore predittivo degli studi preclinici Rivista di Neuroradiologia 7: 595-600.
• de Haën C, Morisetti A., Bertani F., and  Tirone P.  The factor time in acute intravenous toxicity studies of contrast media. Invest Radiol , 29, Suppl. 2, S108-S110, 1994

 PATENTS

• MI2013A000541. Composizione topica per la rimozione dell’emosiderina cutanea (Topical formulation for removal of skin haemosiderin). A. Morisetti, G.Cairo, C.A. Ghisalberti. Filed 08 April 2013

• POSTERS AND ORAL PRESENTATIONS
• Renal contrast retention and histological pictures after injection of non ionic monomeric and dimeric X-ray contrast media. Preclinical findings. 9th Congress ASEAN Association of Radiology  & 6th Scientific Meeting, Singapore Radiological Society. Singapore, 23-26 January 1997. A. Morisetti, V Lorusso, G. Alfieri, P. Lorenzon and P.Tirone.
• POSTER. QT Regulatory requirements to be suited to compounds. The case of MultiHance. M. Castano, A. Morisetti. EPHAR 2004 Porto, 14-17 July 2004
• POSTER Vascular endothelial permeability of paramagnetic contrast media an in vitro model. S. Ramponi, M. Castano, A. Grotti, A. Morisetti, S. Vultaggio, V. Lorusso. EPHAR 2004 Porto, 14-17 luglio 2004
• Margins of safety of intravascular contrast media: body weight, surface area or toxicokinetic approach. S. Bussi, A. Morisetti. CROTOX 2004 Plitvice Lakes (Croatia), 26-28 May 2004
• POSTER. Toxicity of reproduction for in vivo diagnostics suitability of recent FDA proposal. A.Morisetti, S. Bussi) CROTOX 2004, Plitvice Lakes (Croatia), 26-28 May 2004
• Comparison of three different anaesthetic combinations in rats and mice. S. Ramponi, M. Castano, T. Fiorillo, A. Grotti, M. Laucello, L. Tassielli, A. Morisetti. Proceedings of the 8th FELASA Symposium 17-20 June 2002, Aachen, Germany
• POSTER. Efficacy of Tramadol in pain control and welfare improvement in a rat model of chronic arthritis.(S. Ramponi, C. Cabella, A. Grotti, P. Landsberg, A. Morisetti, C. Rebaudengo, S. Vultaggio, V. Lorusso).9th Felasa Symposium, Nantes 14-17 giugno 2004.
• POSTER. An in vitro model to assess the endothelial permeability of paramagnetic contrast media. S. Ramponi, A. Grotti, A. Morisetti, S. Vultaggio, V. Lorusso. 10th International Congress of Toxicology, Tampere 11-15 luglio 2004.
• The Radiological Society of North America, Chicago, Nov 28-Dec 3, 2004. High-Concentration Iomeprol in CT Angiography: Vessel Enhancement in Anaesthetised Swines. C. Catalano, A. Napoli, A.Morisetti, M. Castano, M de Rubeis, R. Passariello
• POSTER. Influence of paramagnetic contrast media an endothelial permeability and morphology: an in vitro model. S. Ramponi, A. Grotti, S. Vultaggio, A. Morisetti, G. Alfieri, V. Lorusso.
• Oral communication: Cardiovascular Safety Pharmacology: un approccio integrato. A. Morisetti, S. Bussi. XIV Congresso Nazionale della Società Italiana di Tossicologia. Istituto Superiore di Sanità, Roma, 6-9 febbraio 2006
• Oral communication: Valutazione preclinica dei radiofarmaci: considerazioni e proposte sulla draft guidance FDA. S. Bussi, A. Morisetti. . XIV Congresso Nazionale della Società Italiana di Tossicologia(SITOX). Istituto Superiore di Sanità, Roma, 6-9 febbraio 2006
• Oral communication: Imaging preclinico: un approccio innovativo a Reduction & Refinement.Convegno Federchimica “R.E.A.Ch. e Metodi Alternativi: applicazioni e partnership pubblico-private. Milano, 21-22 Novembre 2006.
• POSTER: Nonclinical Imaging: a novel approach to Reduction and Refinement.  A. Morisetti, S. Bussi, L. Chaabane, M. Castano.    44th CONGRESS OF THE EUROPEAN SOCIETIES OF TOXICOLOGY. Amsterdam, The Netherlands, 7-10 October 2007
• POSTER: Lu-AMBA, A Novel Compound For The Treatment  of GRP-r Expressing Cancers: Preclinical Safety Assessment. S. Bussi, A. Morisetti. Toxicology Letters Volume 172, Supplement 1, 7 October 2007, Pages S38-S39 Abstracts of the 44th Congress of the European Societies of Toxicology.
• Oral communication: Gd determination in rats’ organs upon i.v. administration of Gd-chelates and Gd-Acetate. Contrast Media Research, Banff, Canada, 16-20 October 2007. Contrast Media & Molecular Imaging Special Issue: CONTRAST MEDIA RESEARCH – CMR 2007 Volume 2, Issue 6, pages 271–273, November/December 2007. http://onlinelibrary.wiley.com/doi/10.1002/cmmi.200/abstract
• Oral communication : Nonclinical imaging: ricerca e sviluppo tossicologico. XVI Congresso Nazionale della Società Italiana di Tossicologia(SITOX). Taormina (ME) 21-23 Marzo 2012. http://www.sitox.org/congresso_12/congresso_abs_view.php?id=56
• POSTER: Toxicological Profile and Tolerability of Pixantrone (Pixuvri) in Newborn Mice Comparative Study with Doxorubicin (DOX). A.M. Giusti, P. A. Colombo, M. Longo, P. Della Torre, A. Morisetti, C. Allievi, and J. Singer. SOT’s 52nd Annual Meeting, San Antonio (Texas, USA) March 10–14, 2013. http://www.toxicology.org/AI/PUB/Tox/2013Tox.pdf PS2098
• European Discussion Group Society of Toxicologic Pathologists. Annual meeting and scientific discussion: “Safety assessment : regulations, extrapolations and common sense”. Dijon, 28-29 November 1991. Oral communication: “Regulations for preclinical studies on contrast agents in Italy”. A. Morisetti.
• XXV Congresso nazionale della Società Italiana di Farmacologia. Taormina Giardini Naxos 14-18 October 1990. Poster : “Factors influencing the acute toxicity of paramagnetic contrast agents”. A. Morisetti, P. Tirone.
• VI International Congress of Toxicology. Rome, June 28-july 3, 1992. Poster: ” The contribution of osmotic load, volume and time required for administration to the toxicity of X-ray contrast media” A. Morisetti, S. Bussi, F. Bertani, M. Grandi, P. Tirone and C.de Haën.

• XXXV Congresso SIRM. IV Incontro mediterraneo di radiologia. Genova, 8-12 November 1992. Oral communication: “Iomeprolo, nuovo mezzo di contrasto non-ionico per mielografia. I. Valutazione preclinica. A. La Noce, A. Morisetti, P.Tirone.
• XVIII Congress of the european society of neuroradiology(ESNR). Sweden Stockholm, 8-11 September 1992 . Oral communication: “Iomeprol: a new non-ionic contrast agent for myelography. Preclinical  investigations”.  A. La Noce, A. Morisetti, P.Tirone.
• Xth Annual Scientific Meeting of the European society for magnetic resonance and medicine in biology (ESMRMB). Rome, 3-6 June 1993. Poster: “Gd-BOPTA/Dimeg: passage through the damaged blood-brain barrier” A. Morisetti, A. La Noce, M. L. Pelaprat, P. Tirone and  C.de Haën.
• XVIIIth International congress of Radiology. Singapore, 23-28 January 1994.  Oral communication : Iomeprol: pharmacokinetic interspecies scaling. V. Lorusso, A. Morisetti,  P. Tirone and  C.de Haën.
• Investigative Radiology 1994 Volume 29, Suppl. 2, S108-S110. Proceedings of the Contrast media research symposium. San Antonio, Texas October 3-8 1993. “The factor time in acute intravenous toxicity studies of contrast media”.  C.de Haën, A. Morisetti, F. Bertani, and  P. Tirone .
• XXXVI Congresso nazionale SIRM (Associazione italiana di radiologia medica). Milano 21-25 May 1994. Poster: Iomeprolo. La tollerabilità sistemica e la neurotollerabilità.” A. Morisetti, P. Gastaldi  and P. Tirone.
• X Congresso nazionale Società Italiana di Tossicologia. Pavia, 21-24 September 1994. Poster: ” Neurotollerabilità dei mezzi di contrasto. Ruolo del volume, dell’osmolalità e del punto di somministrazione. S. Bussi, P. Gastaldi, A. Morisetti , P. Tirone.
• XIth Annual Scientific Meeting of the European society for magnetic resonance and medicine in biology (ESMRMB). Wien, 20-24 April 1994 Poster: “Compatibility of Gd-BOPTA/Dimeg with human blood . In vitro study” R. Valenti, A. Morisetti, P. Tirone.
• VIth International Congress of Nephrotoxicity and Carcinogenicity. Noordwijkerhout, the Netherland, 22 – 24 September 1994. Poster and invited lecture: Renal Histology after Single Dose of Iodinated Contrast Media in Mice. Comparison between Monomers and Dimers. A. Morisetti, S. Bussi, G. Alfieri and P. Tirone.
• Rontgen centenary congress. 100 years of X-rays. Birmingham, UK, 12-16 June 1995. Oral communication: Non-ionic contrast media: preclinical toxicity data and human safety. A. Morisetti, V. Lorusso and P. Tirone.
• First Conjoint Postgraduate Course , International Uroradiology ’96, Zurich, Switzerland, 14-20 June 1996. Invited paper: “Renal responses  in the rat after single intravenous injection of monomeric and dimeric contrast media. The role of osmolality.” Morisetti A, Alfieri G and Tirone P. Bracco SpA, Milano Research Center.
• Seminar on renal physiology and contrast agents, Visby, Gotland  19-20 September, 1996 Invited paper” Renal tubular cell vacuolisation after injection of iodinated monomeric and dimeric contrast media . Preclinical findings”. A. Morisetti, G. Alfieri, V Lorusso, P. Lorenzon and  P.Tirone.
• “47th annual general & scientific meeting. The Royal Australasian College of Radiologists”. Perth (Aus) 5-9 October 1996. Oral communication: Scanning Electron Microscopy in Safety Assessment of Contrast Media. Effects of Non Ionic Contrast Media on Red Blood Cells. Morisetti A, Alfieri G and Tirone P.